Development of an enzyme/yeast-based prebiotic supplement

CPRC
May 14, 2018
By CPRC
Dr. Slominski and his associates have clearly demonstrated the benefits of enzyme/yeast-based prebiotics supplements
Dr. Slominski and his associates have clearly demonstrated the benefits of enzyme/yeast-based prebiotics supplements
Currently, more than 90 per cent of broiler chicken feeds contain enzyme supplements, which have a direct positive effect on animal performance. However, new generation enzyme supplements have been developed for specific use in the feed industry.

Yeast products are rich sources of mannan polysaccharides, ß1,3- and ß1,6-glucans and nucleotides, which can function as prebiotics and have been shown to stimulate the immune system and gastrointestinal tract development. This provides favorable conditions for beneficial intestinal bacteria and results in decreased attachment of pathogens such as Salmonella.

Dr. Bogdan Slominski from the Department of Animal Sciences at the University of Manitoba aimed to develop a product that would contain a combination of a multi-carbohydrase preparation fortified with a yeast cell wall lytic activity with the yeast-derived product(s) as an effective and inexpensive alternative to antibiotic growth promoters.

The experiments
Slominski and his research team conducted a series of experiments to first optimize the depolymerisation of yeast cell wall polysaccharides using varying enzyme activities to explore the potential for the release of bioactive components from various yeast products.

They demonstrated that the use of a specific yeast cell lytic enzyme could significantly depolymerize yeast cell wall polysaccharides so they become water-soluble and, thus, more bioactive. Additionally, yeast cell lysis resulted in the release of a variety of nutrients, including nucleotides, known to play a role in immune system development.

In addition to investigating the effects of enzyme/yeast-based prebiotic supplements on growth performance of broiler chickens and turkeys under commercial field conditions, the researchers also produced different enzyme-pretreated yeast products as dietary enzyme/yeast-based prebiotic supplements. They performed feeding trials with Salmonella and Clostridium perfringens challenged poultry as well.

The findings
The enzyme/yeast-based prebiotic supplements the team developed significantly decreased the incidence of Salmonella shedding and reduced Salmonella cecal counts in broiler chickens and laying hens. In the laying hen, the enzyme/yeast-based prebiotic supplements also reduced Salmonella colonization/numbers in different internal organs.

The Clostridium perfringens challenge study with broiler chickens demonstrated that enzyme/yeast-based prebiotic supplements were as effective as antibiotics in birds post challenge recovery. Other findings of the feeding trials show that enzyme/yeast-based prebiotic supplements fed to broiler chickens suggests a shift in microbial population of the lower gut towards beneficial microbes and a more diversified microbial community, resulting in less susceptibility to pathogenic invasion.

In the broiler chicken study performed under field conditions, researchers observed improvements in body weight gain and feed conversion ratio for diets containing the enzyme/yeast-based prebiotic supplements. In addition, the team observed a significant effect of the enzyme/yeast-based prebiotic supplements on body weight gain and feed conversion ratio in turkeys. Dr. Slominski and his associates have clearly demonstrated the benefits of enzyme/yeast-based prebiotics supplements, which may serve as alternatives to antibiotic growth promoters.

The next steps
The researchers plan to develop yeast products with further enhanced biological activity. Additionally, they aim to investigate the configuration of yeast products required for the bioactive components to exert their activity in protecting the gut from pathogens.

This research is funded by CPRC/AAFC under the Poultry Science Cluster Program. This is in addition to funding from Canola Council of Canada and Canadian Bio-Systems.

CPRC, its board of directors and member organizations are committed to supporting and enhancing Canada’s poultry sector through research and related activities. For more details on these or any other CPRC activities, please contact The Canadian Poultry Research Council, 350 Sparks Street, Suite 1007, Ottawa, Ontario, K1R 7S8, phone: (613) 566-5916, fax: (613) 241-5999, email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it or visit us at www.cp-rc.ca.

CPRC membership consists of Chicken Farmers of Canada, Canadian Hatching Egg Producers, Turkey Farmers of Canada, Egg Farmers of Canada and the Canadian Poultry and Egg Processors’ Council. 

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