Probiotics may offer alternative approach to antimicrobials

OVC
June 05, 2017
By OVC
June 5, 2017, Guelph, Ont. - Research and innovation are key to finding alternatives to antibiotic and antimicrobial use.

Researchers at the Ontario Veterinary College are studying probiotics as an alternative to traditional antimicrobials to combat pathogens including Salmonella, Campylobacter jejuni, and Clostridium perfringens in poultry.

Over the last decade, Dr. Shayan Sharif’s lab at the University of Guelph has been involved in developing probiotic formulations against Salmonella.

“We’ve clearly shown by using combinations of different lactobacilli or lactic acid producing bacteria we can reduce colonization or burden of salmonella in poultry quite significantly,” says Sharif, an immunologist at OVC and leader of the Poultry Health Research Network.

He is now turning his attention to Campylobacter jejuni, the main notifiable bacterial cause of human enteritis or foodborne illness reported to the Public Health Agency of Canada.Chickens can carry Campylobacter in their intestine. While they don’t show any clinical signs of the disease they can carry it throughout their lifetime.

It’s not necessarily a huge concern to the poultry industry because chickens are asymptomatic but a huge concern to human health, as the bacteria can be transferred to humans through undercooked poultry, adds Sharif.

Few control measures, including vaccination, biosecurity or antibiotics, deter the bacteria. Of added concern, both Campylobacter jejeuni and Salmonella can harbor and transfer antimicrobial resistance genes.

Next up for Sharif’s lab will be work on Clostridium perfringens which can cause Necrotic Enteritis, essentially inflammation of the intestine in poultry.

Necrotic Enteritis can be caused by Clostridium perfringens, but usually works with another microorganism called Eimera or coccidia. The two usually go hand-in-hand and coccidia usually predisposes the animal to the pathogenic effects of Clostridium perfringens, notes Sharif. Coccidia is usually controlled by antimicrobials but without treatment there could be a surge in coccidiosis and Necrotic Enteritis, both of which would lead to major drop in production and increased mortality.

While there are vaccines available to combat coccidiosis, this isn’t the case for Necrotic Enteritis.

Sharif’s research includes examining the effect of probiotics on the overall health, welfare and production of poultry. “We want to know if animals as a whole are healthier, if they produce more, if there is better weight gain and if their feed conversion ratio would be better compared to chickens receiving conventional diets.”

Studies will also determine if immune status is improved in birds who receive probiotics.

“At the end of the day if you’re not able to make a probiotic formulation that is safe, that is efficacious, and also able to provide equal production parameters it is not going to be an economically sound investment for producers,” says Sharif.

This research is funded by the Ontario Ministry of Agriculture, Food and Rural Affairs, Canadian Poultry Research Council, Poultry Industry Council and Natural Sciences and Engineering Research Council of Canada.

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